Author

Jared Sterneckert

2 papers indexed here

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Open access Sep 2026

A Human Neuronal Cell Model of Endogenous TDP-43 A315T Reveals Altered Protein Dynamics and Disease-Relevant Cellular Dysfunction

A physiologically relevant human model is established that separates early TDP-43 toxic gain-of-function from basal loss-of-function from basal loss-of-function while providing a robust platform for investigating TDP-43 biology and accelerating therapeutic discovery in ALS.

M. Cicardi, Sara Antonini, Ivette Martorell Serra et al. · bioRxiv · 0 citations

Open access Jul 2026

Deep axonal proteomics of human iPSC-derived neurons by microfluidic separation and DIA-MS

This work combines microfluidic-based axon–soma separation with data-independent acquisition mass spectrometry (DIA-MS) on an Orbitrap Astral mass spectrometer for deep profiling of compartment-resolved proteomes of human induced pluripotent stem cell (iPSC)-derived cortical neurons.

Clemens M Sauter, Zac Sandy, M. Korneck et al. · bioRxiv · 0 citations