Open access
Jul 2026
An IL-34–IGF-1 inflammatory axis fuels KRAS-mutant lung cancer progression
It is shown that KRASG12D mutations in lung epithelium drive proliferation of resident, embryonically-derived alveolar macrophages, which then promote tumor cell proliferation and protection from ferroptosis, leading to tumor progression.
Jaroslav Zak, Hui Chen, Erpei Wang et al.
· bioRxiv · 0 citations