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Jarred Burke

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Oct 2026

Site-Specific N-Glycan-Resolved PK Assessment of Therapeutic Proteins Using Hybrid LBA-HRMS and LC-MS/MS

Understanding how glycosylation and its metabolic conversion shape the pharmacokinetics (PK) and pharmacodynamics (PD) of therapeutic proteins is essential for predicting exposure and efficacy. Lot-to-lot comparisons typically rely on aggregate PK metrics that obscure contributions from individual glycoforms, despite...

Inês C. Santos, Bonnie Wang, Jarred Burke et al. · 0 citations

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