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Author

Jasmina Al-Mousawi

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Open access Aug 2026

High-resolution mapping of embryonic genome activation unveils a decoupling of transcription activation from precocious H3K4me3 removal

The results indicate that precocious removal of H3K4me3 from embryonic chromatin only modestly affects embryonic transcription without perturbing EGA timing, arguing against a major instructive role of precocious remodeling of maternally inherited H3K4me3 after fertilization on genome activation.

Jasmina Al-Mousawi, Luca Michetti, Laura Castaldi et al. · 1 citation · ⚡1

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