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Jason D. Josephson

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Sep 2026

A nitrone-based in vivo click SHAPE reagent for mapping RNA secondary structure

We report the synthesis and testing of a new reagent for selective 2′-hydroxyl acylation analyzed by primer extension (SHAPE). We report the synthesis and testing of a nitrone acyl imidazole that is capable of labelling RNA (DMImO-AI) for applications including in vivo click SHAPE (icSHAPE). The new reagent has a rea...

Jason D. Josephson, Mariam Serhan, E. Scott et al. · 0 citations

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