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Jason J. Colasanti

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Open access Aug 2026

MicroRNA-34a suppresses KLF2 to promote pathological angiogenesis through the CXCR4/CXCL12 pathway in age-related macular degeneration.

A causal link between the age-related miR-34a and neovascularization in AMD is established and miR-34a directly targets and inhibits the transcription factor KLF2, thereby upregulating the proangiogenic factors CXCR4 and CXCL12.

Jason J. Colasanti, A. Santeford, Joseph B. Lin et al. · 1 citation

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