Author

Jason L. Parsons

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Open access Aug 2026

Inhibition of ATM, ATR and DNA-PK radiosensitises 3D uveal melanoma models to X-rays and proton beam therapy

It is demonstrated that inhibition of these protein kinases significantly suppresses the growth of UM spheroids exposed to both X-rays and PBT, which is primarily driven by delayed and persistent DSBs, leading to the accumulation of chromosomal aberrations.

Laura Hawkins, R. Morris, H. Kalirai et al. · Frontiers in Oncology · 0 citations

Review Open access Jul 2026

Recent Progress in Targeting Kinases Involved in the DNA Damage Response for the Treatment of Cancer

The current ATM, ATR, DNA-PK, CHK1, CHK2 and WEE1 inhibitors that show the most promise as monotherapies and combination treatments in solid tumours are discussed, as well as the potential benefits of using TPD technology over small-molecule inhibitors.

Lauryn Buckley-Benbow, Antonia M. Rout, Andrew B. Fielding et al. · TARGETS · 0 citations