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Author

Jason Moffat

2 papers indexed here

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Open access Sep 2026

Cell volume regulation in metazoans involves phosphorylation of TSC22D proteins.

Intracellular water and ion homeostasis are fundamental determinants of cell volume and macromolecular crowding. WNK kinases are central sensors of osmotic stress, yet how their activity is spatiotemporally regulated remains unclear. Here, we identify that TSC22D and NRBP protein families are WNK-dependent substrates....

Seon-Yong Lee, Yu-Xi Xiao, Magali Aguilera-Uribe et al. · 0 citations
Open access Sep 2026

Integrated genetic screening identifies FEN1 as a selective vulnerability and temozolomide resistance mediator in glioblastoma stem cells.

Glioblastoma (GBM) is an aggressive brain tumor characterized by therapy resistance and recurrence. Glioblastoma stem cells (GSCs) are key drivers of tumor maintenance, therapeutic resistance, and relapse, but targeting them remains clinically elusive due to their overlap with normal neural stem cells (NSCs) and a lack...

Benjamin A. Brakel, D. McKenna, Anish Puri et al. · 0 citations

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