Outcomes for pediatric patients with refractory or relapsed T-cell acute lymphoblastic leukemia (T-ALL) are poor, underscoring the need for improved therapeutic strategies. CD38, a type II transmembrane glycoprotein, is a promising target in T-ALL, with clinical trials evaluating CD38-targeting immunotherapies in front...
R. Shraim, Gong-Ping Shi, Yi-Zhen Li et al.· Blood· 0 citations
Abstract Genomic DNA encodes regulatory information that determines where, when, and to what extent genes are expressed. Theoretically, we should be able to identify these transcriptional “instructions” by examining genomic DNA sequence alone, yet this has remained challenging. Here we present the Vertebrate Regulatory...
Tássia Mangetti Gonçalves, Casey L. Stewart, Samantha D. Baxley et al.· NAR Genomics and Bioinformat...· 0 citations
Early-phase studies of deep B cell depletion with anti-CD19 chimeric antigen receptor (CAR) T have produced prolonged, drug-free remission in refractory autoimmune disease. However, CAR T cell therapy requires lymphodepleting chemotherapy, autologous cell manufacturing and specialized infrastructure, limiting reach to...
Jason Xu, Chun-Li Mei, Xin Guan et al.· Nature Medicine· 0 citations
We introduce WC2026-Agents, a benchmark and dataset for evaluating large language models (LLMs) as autonomous forecasting agents on real, future events. For every one of the 104 matches of the 2026 FIFA World Cup, four frontier models -- Claude Opus 4.8, ChatGPT (GPT-5.5, high reasoning), Gemini 3.1 Pro, and Grok (Expe...
Jiachen Ding, Congyu Guo, Jason Xu· arXiv.org· 1 citation
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