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Javier Reig-López

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Open access Sep 2026

PBPK model of carbamazepine and its metabolite for bioequivalence assessment: prioritizing early exposure and single-dose study designs.

A physiologically based pharmacokinetic (PBPK) model for carbamazepine (CBZ) was calibrated against an intravenous clinical dataset. Absorption was characterised using the Advanced Dissolution, Absorption and Metabolism (ADAM) model coupled to the diffusion layer model and a particle population balance framework, incor...

Javier Zarzoso-Foj, Marina Cuquerella-Gilabert, Javier Reig-López et al. · 0 citations

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