Open access
Sep 2026
Accelerated discovery of thermostable mRNA-lipid nanoparticle vaccines using data-efficient AI.
The instability of mRNA-lipid nanoparticles (LNPs) necessitates ultra-cold storage, limiting global distribution and their broader application in advanced delivery systems. Solid-state, water-free formulations enhance thermostability and enable integration into emerging delivery modalities such as microneedle patches....
Jin-Bi Tian, Khanh T. M. Tran, Brett H. Pogostin et al.
· Nature Biotechnology · 0 citations