Author

Jayanta Kundu

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Oct 2026

Synthesis and Characterization of Aminooxy Click Chemistry-Mediated Bis -Conjugates of siRNAs and Evaluation of Their RNAi Activity

Previously, we used an aminooxy click chemistry (AOCC) strategy to introduce pairs of ligands into oligonucleotides during solid-phase synthesis by using nucleoside and non-nucleoside building blocks. However, the standard oligonucleotide synthesis conditions were incompatible with the incorporation of certain comple...

Dhrubajyoti Datta, Mark Neil Tolentino, Mimouna Madaoui et al. · Bioconjugate chemistry · 0 citations

Open access Sep 2026

Chiral-4′-Methyl-α‑(l)‑Threofuranosyl Nucleic Acids: Synthesis, Structure, Binding Affinity, Nuclease Resistance, and Polymerase Recognition

α-(l)-(3′–2′)-Threofuranosyl nucleic acid (TNA) cross-pairs with DNA and RNA and is not degraded by nucleases and thus has potential for use in diagnostics and therapeutics based on nucleic acids. Here, we describe the synthesis of 15 building blocks of chiral 4′-(R)- and 15 building blocks of chiral (S)-methyl-α-(l)-t...

Atsushi Mikami, Dhrubajyoti Datta, Jayanta Kundu et al. · Journal of the American Chem... · 0 citations