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Author

Jean-François Gautier

2 papers indexed here

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Aug 2026

Immunometabolic endotypes define distinct clinical trajectories in type 2 diabetes.

Type 2 diabetes (T2D) is a heterogeneous disease, yet current classifications do not capture its clinico-biological complexity or support precision-based care. We developed an endotyping strategy based on routine blood immune cell counts across more than 1,500 individuals with newly diagnosed T2D from three European co...

B. Vuong, Chloe Delepine, Jacqueline M. Ratter-Rieck et al. · 0 citations
Review Jul 2026

Insulin resistance and type 2 diabetes as allostatic responses to chronic nutrient excess.

Obesity-related type 2 diabetes (T2D) is currently defined by insulin resistance and impaired insulin secretion. Sulfonylureas, thiazolinediones, and insulin are effective at lowering glycemia yet have not consistently translated into improved long-term outcomes. In contrast, recent interventions often produce metaboli...

M. Prentki, Christopher J. Nolan, David E. James et al. · 0 citations

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