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Author

Jean-François Goût

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2 papers indexed here

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Review Open access Sep 2026

Survey of transcription initiation in the streamlined genomes of Paramecium

In the genus Paramecium, the macronuclear genome is remarkably compact and optimized for gene expression. As a means to explore eukaryotic transcription in the context of a streamlined genome and shed light on the role of sequence architecture on gene expression and loss, we analyzed the distribution and diversity of c...

Berenice Jiménez-Marín, Darian Stickling, Tia Swenty et al. · 0 citations
Open access Sep 2026

Temporal control of mitochondrial mutagenesis reveals the fate of mtDNA mutations with age

Mutations in the mitochondrial genome (mtDNA) play a critical role in the aging process and a wide variety of age-related diseases. However, it remains unclear when the mutations that drive physiological decline arise. To answer this question, we generated a new mouse model in which mitochondrial mutagenesis can be con...

Sarah J. Shemtov, Eric Hwang, Claire S. Chung et al. · 0 citations

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