Open access
Aug 2026
In vivo CRISPR screening identifies metastasis suppressors in triple-negative breast cancer
An unbiased in vivo genome-wide CRISPR/Cas9 loss-of-function screen in a breast cancer xenograft model uncovers clinically relevant metastasis suppressor genes (MSGs), including VPS45, CMTR2, RBSN, and NF2, whose loss enhances lung colonization.
Soaad Galal, Leslie Chaltel Lima, Ni Wang et al.
· Nature Communications · 0 citations