Ultrashort (US) cell-free DNA (cfDNA) is a population of approximately 50-nucleotide single-stranded DNA molecules in human plasma.1–3 Although it holds biological and diagnostic potential, US cfDNA escapes detection by conventional double-stranded library preparation methods.1–3 Independent studies have linked US cfDN...
Martin Gajarský, Olivia van Ray, Thomas Akkermann et al.· bioRxiv· 0 citations
ABSTRACT Malaria caused by Plasmodium falciparum remains a major health threat, killing over 600,000 people annually. The spread of resistance to all major antimalarials, including artemisinins, highlights the urgent need for new drugs with distinct mechanisms of action. Here, we show that the G-quadruplex ligand RHPS4...
Mariam Salim, L. Paloque, F. Nardella et al.· Antimicrobial Agents and Che...· 0 citations
G4All, a comprehensive, curated database of G4-forming short DNA and RNA sequences, complemented by rigorously selected non-G4 controls, is introduced, enabling rigorous comparative analyses, assay benchmarking, and the development of predictive models.
Parth Rajput, Anne Cucchiarini, Dmitrii Trubetskoy et al.· bioRxiv· 0 citations
GG is established as a powerful but context-dependent G-quadruplex stabilizer and design principles for its use in engineered G-quadruplexes and aptamer development are defined.
Krista Urup, Peter Reinholdt, Kasper M. Beck et al.· Chemistry· 0 citations
The results indicate that G-quadruplex-prone sequences represent a common genomic feature associated with a number of human transcription factors and chromatin-associated regulatory proteins and support a model in which G4-rich regions act as selective regulatory scaffolds shaping transcription factor occupancy and gen...
Karolína Drápalová, Michaela Dobrovolná, Filip Kledus et al.· BMC Genomics· 0 citations
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