Open access
Sep 2026
A high-density CRISPR activation platform for mapping cancer dependencies and resistance pathways ex vivo and in vivo
CRISPR activation (CRISPRa) enables precise up-regulation of gene expression for ex vivo and in vivo applications. However, a lack of scalable, high-coverage tools has limited comprehensive genetic screening in murine models. Here, we introduce Partita, a next-generation mouse whole-genome CRISPRa sgRNA platform, desig...
Sarah T. Diepstraten, Yexuan Deng, Margaret A. Potts et al.
· Science Advances · 0 citations