Author

Jean-Sébastien Silvestre

2 papers indexed here

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Open access Oct 2026

Cell-specific isolation and functional analysis of primary cardiomyocyte-derived large extracellular vesicles from infarcted mouse hearts

Extracellular vesicles (EVs) are membrane-bound particles secreted by all cells and serve as critical mediators of intercellular communication in both physiological and pathological contexts. However, elucidating the precise functions of endogenous EVs remains challenged by a fundamental technical bottleneck: current i...

L. Borowski, A. Ramazanova, P. Alayrac et al. · bioRxiv · 0 citations

Open access Aug 2026

TREM2 drives accumulation of pro-scarring monocyte-derived macrophages in the infarcted myocardium

Myocardial infarction is a leading cause of death and disability worldwide. Ischemic injury leads to irreversible loss of cardiomyocytes, the contractile cells of the heart, and formation of a fibrotic scar. After infarction, macrophages massively infiltrate the heart and orchestrate the tissue repair process by removi...

Giuseppe Rizzo, Marie Piollet, T. Krammer et al. · bioRxiv · 0 citations