Author

Jee Hyun Kim

2 papers indexed here

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Review Open access Aug 2026

Gut microbiome: a key driver and therapeutic target of intestinal fibrosis in Crohn's disease.

It is suggested that targeting the microbiome-fibrosis axis, through precision modulation of the microbiome or metabolite-based interventions, represents a promising frontier for preventing and reversing fibrostenotic Crohn's disease.

Jee Hyun Kim, Y. Choi, J. H. Yoo · Intestinal Research · 0 citations

Open access Aug 2026

Roflumilast Inhibits Fibrogenic Activation in Human Intestinal Myofibroblasts via Inhibition of Myocardin-Related Transcription Factor/Serum Response Factor Signaling

Findings indicate that PDE4 inhibitors, particularly roflumilast, effectively suppress TGF-β1-induced fibrogenic activation in HIMFs by modulating MRTF/SRF and Smad-dependent pathways, highlighting the value of roflumilast for further preclinical investigation as a potential therapeutic strategy for intestinal fibrosis...

Dongju Lee, Y. Choi, In-Kyung Yoo et al. · International Journal of Mol... · 0 citations