Open access
Jul 2026
Notch2 signaling instructs viral and bacterial TLR responsiveness in B cells.
Marginal zone (MZ) B cells optimize protection against blood-borne bacteria by rapidly producing plasma cells in response to Toll-like receptor (TLR) ligands. Here, we demonstrate that Notch2 instructs this responsiveness for both the dsRNA sensor TLR3 and LPS sensor TLR4. Using mathematical modeling of cell trace time...
Jennifer Londregan, Isaiah Rozich, Brian T. Gaudette et al.
· Cell Reports · 0 citations