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Author

Jeffrey W. Bode

2 papers indexed here

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Open access Sep 2026

A designed ubiquitin-binding protein selectively enriches and visualizes unanchored ubiquitin

While protein ubiquitination has been extensively studied, the roles of unanchored ubiquitin and its chains remain less understood, largely due to a lack of specific, high-affinity tools for their enrichment and visualization. To address this, we used high-throughput affinity maturation and computational protein design...

Shi-Hua Shi, A. Bendel, G. Kempf et al. · 0 citations
Open access Sep 2026

Modular assembly and property profiling of an expansive, shape-defined library of pentacyclic saturated N-heterocycles

Small-molecule drug discovery is increasingly applied to targets historically classified as “undruggable”, such as non-coding RNAs and biomolecular interactions. These complex interfaces demand ligands with greater three-dimensional complexity and preferred physicochemical profiles that are deficient in typical small m...

E. Boschi, Dmitry Mazunin, Alex Mueller et al. · 0 citations

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