Open access
Aug 2026
Evolutionary conservation analysis reveals a primordial function of STING as a regulator of lipid metabolism via FADS2
The stimulator of interferon genes (STING) is a pivotal regulator of type I interferon (IFN) responses. Although the IFN system is confined to vertebrates, STING is present across metazoans and in some unicellular eukaryotes, suggesting involvement in distinct functions prior to vertebrate divergence. Here we explore t...
Soumyabrata Guha, Joanna Re, S. Grégoire et al.
· Nature Communications · 0 citations