Open access
Aug 2026
The default mode network exhibits circuit-specific selective vulnerability despite widespread amyloid burden in an animal model of Alzheimer’s disease
In Alzheimer’s Disease (AD) the default mode network (DMN) exhibits selective vulnerability to functional decline and amyloid beta (Aβ) plaques in early AD. DMN vulnerability may simply be the result of Aβ accumulation. Alternately, Aβ may unmask an intrinsic susceptibility of DMN circuits. Should DMN vulnerability per...
Samuel J. Brunwasser, James N. McGregor, Kiran Bhaskaran-Nair et al.
· Nature Communications · 0 citations