Author

Jennifer E. Phillips-Cremins

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Jun 2025

Persistent chromatin alterations and gene expression reprogramming follow widespread DNA damage in glioblastoma

DNA damage from routine cellular processes or exogenous insults can have a lasting impact on gene regulation beyond genetic mutations. The prevailing paradigm for the consequences of DNA damage repair revolves around restoration of the original genetic sequence, but long-term changes in chromatin configuration, gene ex...

A. Modrek, K. Chandradoss, Catherine Do et al. · bioRxiv · 0 citations

Open access Aug 2026

Integrative spatial profiling of 3D genome organization and gene expression in tissue

Spatial Hi-C-RNA provides a broadly applicable framework for investigating genome structure–function relationships in development and disease within native tissue environments within native tissue environments.

Pengfei Guo, Yan Cui, Jin-Can He et al. · Cell · 0 citations