Author

Jenny M. Hogstrom

2 papers indexed here

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Open access Sep 2026

A noncanonical function of the tyrosine degradation enzyme FAH drives CDK4/6 inhibitor resistance in breast cancer

Resistance to standard-of-care therapies remains a major clinical challenge in the treatment of the most common breast cancer, the hormone receptor–positive (HR+) subtype. Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors improve outcomes in early-stage HR+ disease, yet many patients relapse. Resistance mechanisms of rel...

Jenny M. Hogstrom, Hanna M. Doh, A. Kump et al. · Science Advances · 0 citations

Open access Sep 2026

MAPK signaling links BRD2 chromatin occupancy to PI3K/AKT inhibitor sensitivity

Bromodomain and extra-terminal (BET) proteins, BRD2, BRD3, BRD4, and BRDT, couple histone acetylation to transcription by recruiting elongation and transcription factor complexes to chromatin. Although BET proteins are promising therapeutic targets, the functions of individual family members remain incompletely underst...

Josefina Mendez, Simone Bruno, Alexandra Indeglia et al. · bioRxiv · 0 citations