The transport of about 70 enzymes to lysosomes depends on mannose 6-phosphate signals formed by GNPTAB. Editing of Gnptab in an intestinal mouse cell line revealed the loss of multiple lysosomal enzymes associated with the accumulation of sphingomyelins, ceramides, and cholesterol, and reduced levels of bis(monoacylgly...
Gianmarco Del Gallo, Zi-Lei Chen, Anne Sanner et al.· bioRxiv· 0 citations
It is found that the mutations induce distinct transcriptional and translational alterations: rN-Alpha drives a stealth-like infection characterized by sustained translation efficiency and specific evasion of the 2’-5’-oligoadenylate synthetase (OAS) innate immune sensor, whereas rN-Delta and rN-BA trigger a highly ele...
J. Berger, Jonas Schröder, Timothy K. Soh et al.· bioRxiv· 0 citations
A virion-wide spatial and quantitative protein proximity map of herpes simplex virus 1 (HSV-1) is defined by combining cross-linking mass spectrometry with quantitative proteomics, showing how conserved organizational principles shape virus-specific virion interaction networks during herpesvirus maturation.
Lars Mühlberg, Yannick Jensen, Julia Ruta et al.· bioRxiv· 0 citations
The findings show that bacterial virulence can be regulated through environmentally controlled transitions between protein assemblies, identifying membrane accumulation as a promising anti-virulence target.
Sambhasan Banerjee, V. Skoryk, Bader Rayan et al.· bioRxiv· 0 citations
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