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Jeongmin Lee

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Open access Oct 2026

Metabolic stress exacerbates Ca2+ dysregulation and arrhythmias in catecholaminergic polymorphic ventricular tachycardia.

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a genetic arrhythmic syndrome caused by mutations in the sarcoplasmic reticulum (SR) calcium (Ca2+) release channel RyR2 or its accessory proteins, including calsequestrin-2 (CASQ2). RyR2 dysfunction or leak is the hallmark feature of CPVT and directly tri...

Valeria Gomez, Arpita Deb, Zhuo-Xin Li et al. · 0 citations

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