Open access
Oct 2026
Uridine Bisphosphonate-Carbagalactose: A Stabilized α‑1,4-Galactosyltransferase Inhibitor
Methylene and difluoromethylene uridine bisphosphonate carbagalactose were designed and synthesized as stable uridine diphosphate-galactose (UDP-Gal) mimics for probing α-1,4-galactosyltransferase (A4GALT). In these analogues, the labile glycosidic and pyrophosphate linkages of UDP-Gal are replaced by chemically and en...
Jian-Yun Guo, Nicky de Koster, Bob van Puffelen et al.
· Organic Letters · 0 citations