Author

Jerry S. H. Lee

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Review Open access Sep 2026

Big Data and Artificial Intelligence in Cancer Drug Discovery: Promise, Challenges, and Emerging Opportunities

Simple Summary Only 4.1% of potential cancer therapeutics reach the clinic despite taking roughly fourteen years to develop at a cost of more than a billion USD. Large datasets and artificial intelligence (AI) are promising new tools to improve the odds. Cancer drug discovery produces enormous amounts of data related t...

Fakhar U. Singhera, J. Overhulse, Terrence M. Lee et al. · Cancers · 0 citations

Jul 2026

Abstract B077: EMI-1725 Demonstrates Broad Antagonist Activity Against Drug-Resistant Androgen Receptor Mutations and Tumor Growth Suppression in Preclinical Models of Metastatic Castration-Resistant Prostate Cancer

In vitro and in vivo findings support the advancement of EMI-1725 as a promising therapeutic candidate for mCRPC, which showed improved biodistribution across organs and displayed less accumulation in the brain compared to enzalutamide, where off-target binding leads to risk of seizure.

S. Kregel, R. J. Kostlan, John T. Phoenix et al. · Clinical Cancer Research · 0 citations