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Author

Jesper Emil Jakobsgaard

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Open access Oct 2026

Diabetic Polyneuropathy Patients Exhibit an Altered Skeletal Muscle Proteome Phenotype

ABSTRACT Purpose Diabetic polyneuropathy (DPN) is a debilitating complication of diabetes that affects motor nerves and may impair skeletal muscle health. This study investigated skeletal muscle proteomic alterations associated with DPN compared with type 2 diabetes without DPN (T2D) and healthy controls (CON). Experim...

F. Thybo, K. Khan, Jesper Emil Jakobsgaard et al. · 0 citations
Open access Aug 2026

Aging preserves mTORC1 but attenuates JNK-SMAD2L signaling sensitivity to passive stretch-induced tension development in isolated mouse skeletal muscle.

The findings reveal that mechanosensitive anabolic signaling is differentially affected by aging, and suggests that age-related deficits observed in vivo may, at least in part, arise from systemic influences rather than intrinsic defects adhering to mTORC1 mechanotransduction.

J. B. Kristiansen, Jacob Andresen, Jesper Emil Jakobsgaard et al. · 0 citations

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