Author

Jesse G. Meyer

2 papers indexed here

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Open access Sep 2026

The p53–p21–Cyclin D2 regulatory axis drives metabolic reprogramming and a distinct senescent macrophage senotype during aging and MASLD

Aging drives chronic disease in part through senescent cells, including macrophages, which fuel inflammation. Senescent macrophages are functionally heterogeneous: canonical p16-high macrophages promote tumorigenesis or, in other contexts, disease tolerance, whereas we previously identified a distinct p21-high, p16-low...

Grasiela Torres, Ivan A. Salladay-Perez, Christina Y. Deng et al. · bioRxiv · 0 citations

Open access Aug 2026

Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity

The findings establish the retina as an early site of AD synaptopathy and position UCHL1 as a candidate biomarker and mechanistic mediator linking amyloid pathology, neuroinflammation, and synaptic vulnerability.

A. Rentsendorj, Jean-Philippe Vit, Alexandre Hutton et al. · Advancement of science · 0 citations