Author

Jesse Luke

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Open access Aug 2026

Oncogenic transformation proceeds through a transient state of cellular plasticity constrained by lineage-specific barriers

These findings support a model in which normal-like cells tolerate oncogenic mutations not because most cells fail to respond, but because a p53-independent, cell-intrinsic barrier limits the stabilization of malignant transformation following a transient period of heightened plasticity.

Costakis Frangou, A. Safina, M. Commane et al. · bioRxiv · 0 citations