Author

Jesse M. Gray

3 papers indexed here

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Open access Oct 2026

A DNA Typewriter records the cell lineage history of a mouse, from zygote to late organogenesis.

Mammalian biology unfolds over time, within tissues and organs opaque to our eyes and instruments. We applied DNA Typewriter, a sequential molecular recorder, to record the cell lineage of a mouse over nearly two weeks of development. From one embryo, we reconstruct a time-calibrated, parsimony-supported, zygote-rooted...

Qi Yu, Haedong Kim, S. Seidel et al. · Science · 3 citations

Open access Jul 2026

In vivo reconstruction of the cell lineage history of a developing mouse with DNA Typewriter, from zygote to late organogenesis

DNA Typewriter, a sequential molecular recorder, was applied to record the cell lineage of a mouse over nearly two weeks of development, reconstructing a time-calibrated, parsimony-supported, zygote-rooted phylogeny of 1.28M transcriptionally-profiled cells.

Qi Yu, Haedong Kim, S. Seidel et al. · bioRxiv · 1 citation

Open access Jul 2026

In vivo reconstruction of the cell lineage history of a developing mouse with DNA Typewriter, from zygote to late organogenesis

The complete cell lineage of C. elegans, mapped over four decades ago, was tractable because the animal is small, transparent, and lineage invariant1. Most animals are none of these, having orders of magnitude more cells, being opaque, and developing with substantial stochasticity2. Since 2016, genome editing-based lin...

Qi Yu, Haedong Kim, S. Seidel et al. · bioRxiv · 0 citations