Jesselin J. Romero Escobar

Developmental differences in platelet P-selectin expression modulate neonatal monocyte inflammatory responses.

Neonatal and adult platelets are functionally different, with neonatal platelets being comparatively hypo-reactive to multiple platelet agonists. When transfused, neonates receive platelets from adult donors, resulting in a cellular developmental mismatch. Platelets are key regulators of the monocyte inflammatory respo...