Open access
Sep 2026
Activating a patient-relevant pathogenic variant of a genetically defined heart disease in a humanized pig model
The study describes the generation of a humanized pig model carrying an inducible phospholamban R14del mutation for cardiomyopathy modeling and demonstrates Cre-based activation strategies as efficient alternatives to germline Cre-driver lines in large animals.
Petra Runa-Vochozkova, M. Vaškovičová, J. Cambra et al.
· Lab animal · 0 citations