Author

Jessica L. Smith

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Open access Aug 2026

Discovery of a 4′‐Azido Fleximer Nucleoside Analog With Broad‐Spectrum Antiviral Activity Against DENV, EBOV, and Other RNA Viruses

The ongoing emergence and reemergence of RNA viruses from multiple viral families highlights the urgent need for broad‐spectrum antiviral therapeutics. To address this issue, a series of 4′‐azido fleximer nucleoside analogs were synthesized and evaluated for broad‐spectrum antiviral activity against pathogens of epidem...

Kyle A. Davis, Ryan L. Slack, Thomas R. Foulkes et al. · ChemMedChem · 0 citations

Open access Sep 2026

Evaluation of a Zika virus-like particle-based vaccine in a highly penetrant non-human primate model of congenital infection

Zika virus (ZIKV) is an arthropod-borne Orthoflavivirus that caused a major outbreak in Central and South America in 2015–16. During that outbreak, ZIKV infection during pregnancy was associated with high rates of adverse outcomes, including miscarriage and a spectrum of neurological birth defects collectively termed c...

Hannah K. Jaeger, Jessica L. Smith, C. Labriola et al. · PLoS Neglected Tropical Dise... · 0 citations