Review
Open access
Oct 2026
From aggregate structure to disease trajectory: the role of the proteostasis network
Abstract Neurodegenerative diseases are characterized by the accumulation of a small number of misfolded proteins, yet they differ markedly in cellular vulnerability and clinical outcome. We propose that this heterogeneity arises from the interaction between two largely orthogonal variables: the structural identities o...
Jessica Tittelmeier, C. Nussbaum-Krammer
· Philosophical transactions o... · 0 citations