Duplicated CYP71D enzymes promote metabolic innovation through regiospecific oxidation at a sesquiterpenoid biosynthetic locus in Medicago truncatula.
Sesquiterpenoid chemical diversity is frequently generated through cytochrome P450 (CYP)-mediated oxidation of terpene scaffolds. In Medicago truncatula, the sesquiterpene alcohol himachalol, produced by the terpene synthase MtTPS10, has been implicated in pathogen defense, yet the enzymes responsible for its downstrea...