Immunoinformatics-driven design and in silico evaluation of a multi-epitope vaccine candidate against Orientia tsutsugamushi causing scrub typhus
Despite decades of research, an effective vaccine against Orientia tsutsugamushi remains unavailable owing to the pathogen's high antigenic variability, intracellular persistence, and poor cross-protection between strains. This study was conducted to develop a conserved multi-epitope vaccine candidate against the 56kDa...