Jhih-Wei Chu

Chemical-scale force responses across G-quadruplex topologies via machine learning.

G-quadruplexes (GQs) are four-stranded DNA structures formed by guanine-rich sequences and can act as regulatory impediments in gene expression. The core of GQ consists of stacked layers of Hoogsteen-paired guanine bases (G-tetrads), which can arise from various topologies adopted by the backbone strands of guanine tra...