Author

Jichen Zhang

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Open access Sep 2026

VeloHARMO: a deep learning framework for mRNA coding sequence generation and design via translation velocity harmonization

Abstract Heterologous gene expression often results in suboptimal protein yield or activity, potentially influenced by differences in translation dynamics between native and host organisms. Conventional mRNA design approaches based on codon usage frequency can improve expression efficiency. However, codon usage frequen...

Bian Bian, Ji-Chen Zhang, Yi-Ming Zhang et al. · Briefings in Bioinformatics · 0 citations

Open access Aug 2026

FAM136A is an essential chaperone for mitochondrial membrane protein biogenesis

It is concluded that FAM136A is an IMS-resident chaperone, necessary and sufficient to maintain nascent membrane proteins in a folding-competent state to mediate their integration into the bilayer.

M. Ernst, Jichen Zhang, Haoqi Xu et al. · bioRxiv · 0 citations