Ji-Kai Yang

HIF-1α-Driven Protein Lactylation Promotes Ferroptosis and Lipid Peroxidation in Ulcerative Colitis and Is Suppressed by Quercetin.

Ulcerative colitis (UC) is associated with a hypoxic microenvironment that stabilizes hypoxia-inducible factor-1α (HIF-1α), driving glycolytic flux and lactate accumulation. Ferroptosis, an iron-dependent cell death process linked to lactate metabolism, has been implicated in UC pathogenesis; however, whether HIF-1α re...