Ji-Sun Yoo

Oxygen-responsive bacterial glycosphingolipid links symbiont fitness and immune development in neonatal host

Summary Symbiotic gut bacteria must re-establish themselves in every host generation, yet the molecular strategies enabling this inheritance remain poorly understood. Here we show that Bacteroides fragilis uses a membrane glycolipid, alpha-galactosylceramide (BfaGC), to colonize the neonatal gut. Genome-wide fitness pr...