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Author

Ji-Wei Zhang

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Review Open access Sep 2026

The substrate envelope strategy: Structural basis for resistance mitigation in antiviral drug design

Drug resistance remains a major hurdle in antiviral drug development. This review highlights the “substrate envelope hypothesis”, a structure-based drug design (SBDD) paradigm that constrains the spatial boundaries and binding footprint of inhibitors within the conserved active site volume defined by natural viral subs...

Qiao-Ji Xu, Ji-Wei Zhang, Yan-Xu Hou et al. · 0 citations
Sep 2026

Small-Molecule Antivirals against Severe Fever with Thrombocytopenia Syndrome Virus: From Viral Life Cycle Targets to Host-Directed Strategies

Severe fever with thrombocytopenia syndrome virus (SFTSV), an emerging tick-borne bunyavirus with a case fatality rate of up to 30%, poses a growing threat to global public health. No approved specific antivirals are currently available. This perspective critically evaluates recent advances in the development of smal...

Zhou Tan, Ji-Wei Zhang, Chun-Hong Yin et al. · 0 citations

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