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Longitudinal biopsies, spatial multi-omics, humanized models and biomarker-defined trials are needed to distinguish causal vulnerabilities from correlates of treatment-emergent lineage transition.
The AEN score is a robust prognostic tool linking PCD activity to PCa aggressiveness and immune evasion and EZR emerges as a functional effector and potential therapeutic target acting through Hippo signaling in PCa.
A spatiotemporally programmable supramolecular approach that integrates lysosomal disruption with innate immune activation to overcome therapeutic resistance and immunosuppression in PCa is established.
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