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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Jia-Bao Wu

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Open access Sep 2026

Targeting the CAF-LPL-STAT3 axis mitigates osimertinib resistance associated with EGFR downregulation.

BACKGROUND Acquired resistance to osimertinib in epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) arises from both tumor cell-intrinsic pathways and tumor microenvironmental cues. Cancer-associated fibroblasts (CAFs) are critical stromal components that drive therapeutic resistance, yet...

Fei Ye, Jia-Bao Wu, Di Liu et al. · 0 citations

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