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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Jiabin Li

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Aug 2026

A Kinetic Origin of Vps34-IN-3 Selectivity for VPS34 over PI3Kα Revealed by Supervised Molecular Dynamics and Potential of Mean Force Analysis.

The rational design of selective kinase inhibitors is hampered by the conserved ATP-binding pockets. Vps34-IN-3, a potent VPS34 inhibitor developed by Genentech, Inc., showed ∼95-fold selectivity over the closely related PI3Kα, yet the atomic-level mechanism underlying this selectivity remains unclear. Here, we combine...

Liang Yu, Qianqian Dong, Qi-Qi Han et al. · 0 citations
Open access Oct 2026

Association of Early Minocycline Use with Secondary Infections in Patients with Severe Fever with Thrombocytopenia Syndrome: A Multicenter Retrospective Cohort Study

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infection disease in which secondary infections may worsen clinical outcomes, particularly in severe cases. This multicenter retrospective cohort study included 1975 laboratory-confirmed SFTS patients from three hospitals in Anhui, China (2011...

Yuan-Yuan Zhang, Yuan Jiang, Xu-Ya Yuan et al. · 0 citations

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