Brucellosis remains an important zoonosis, but evidence on the diagnostic accuracy of serological assays in Bactrian camels is limited. We conducted a cross-sectional study involving 1091 Bactrian camels from 24 herds in Alxa Right Banner, Inner Mongolia, China. Serum samples were tested using the Rose Bengal test (RBT...
Heleer Cha, Yu Feng, Ru-Na Cha et al.· Preventive Veterinary Medici...· 0 citations
Brucellosis is a globally important zoonosis with major impacts on the sheep industry and public health. However, current research efforts mainly rely on heterologous models and vaccine-induced immunity, which fail to accurately capture the host-specific immune mechanisms underlying natural Brucella infection in...
ABSTRACT For Brucella spp., the ability to invade and survive within host macrophages is essential for causing chronic infections in their mammalian hosts. In this study, a genome-wide CRISPR knockout screen was performed for the first time in human THP-1 macrophages to identify host genes mediating resistance to Bruce...
Xinhui Wang, Sujun Wu, Yi-Ge Ding et al.· Emerging Microbes and Infect...· 0 citations
ABSTRACT The type IV secretion system (T4SS) acts as the central virulence determinant of Brucella, facilitating intracellular survival via the secretion of effector proteins. In this study, we combined bioinformatic prediction with translocation assays to identify seven novel VirB-dependent effectors. Functional chara...
Schmallenberg virus (SBV) is a transboundary animal pathogen that causes reproductive disorders in ruminants, necessitating standardized molecular surveillance. Adhering to the Chinese national standard GB/T 43159—2023, we developed armored RNA quality control materials using MS2 bacteriophage technology targeting the...
