Author

Jia-Chao Wang

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Review Open access Sep 2026

From Gut Microbiota to Hepatic Pre-Metastatic Niches: Mechanism and Translational Prospects of the Gut–Liver Axis in Regulating Colorectal Cancer Liver Metastasis

Colorectal cancer (CRC) is one of the most common malignancies worldwide, and liver metastasis remains a major contributor to poor prognosis and treatment failure. Increasing evidence indicates that the gut–liver axis plays a critical role in colorectal cancer liver metastasis (CRLM) by linking intestinal microbial alt...

Shi-Yi Wang, Jia-Chao Wang · Microorganisms · 0 citations

Open access Aug 2026

NETs drive CD4⁺ T cell dysfunction in sepsis via mitochondrial ROS and impaired calcium signalling

Sepsis is a life-threatening condition with high mortality, in which sepsis-induced immunosuppression—characterized by CD4+ T cell dysfunction and apoptosis—worsens clinical outcomes. The mechanistic link between neutrophil extracellular traps (NETs) and CD4+ T cell fate in sepsis remains poorly elucidated. We integrat...

Hong-Ru Li, Xuan Wang, Ke-Ran Sun et al. · Molecular Medicine · 0 citations