Abstract Background Gastric cancer ovarian metastasis (GCOM) is an aggressive clinical entity whose evolutionary dissemination routes and molecular features remain incompletely defined. Methods We performed whole‐exome sequencing and patient‐level phylogenetic reconstruction of 81 spatially distinct tumour specimens fr...
Pei-Yu Zhu, Xiao-Fang Xing, Ke Ji et al.· Clinical and Translational M...· 0 citations
Tumor-derived model biobanks comprise patient-derived xenografts, organoids, cell models or cultures, and selected paired derivatives linked to clinical, pathological, molecular, and functional data. In China, patient-derived organoid and xenograft resources have expanded through clinical and academic studies, enterpri...
Lian-Hai Zhang, Ying Hu, Haixin Li et al.· Biopreservation and Biobanki...· 0 citations
This study revealed that cisplatin could promote ecDNA generation, which enhanced malignant phenotypes, including cell proliferation, motility and drug resistance, and was associated with poorer patient prognosis, and targeting ecDNA with inhibitors could reverse these effects.
Huanbo Zhu, Lian Chen, Long-Tao Huangfu et al.· Journal of Advanced Research· 0 citations
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